lack of association between mirna-146a rs2910164 and mirna-499 rs3746444 gene polymorphisms and susceptibility to pulmonary tuberculosis
نویسندگان
چکیده
single-nucleotide polymorphisms (snps) in mirnasmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. our study aimed to evaluate the possible association between mirna-146a rs2910164 and mirna-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (ptb) in a sample of iranian population. this case- control study was performed on 202 ptb patients and 204 healthy individuals. genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (t-arms-pcr). the results indicated that neither mirna-499 rs3746444 nor mirna-146a rs2910164 are associated with the risk of ptb in a sample of iranian population. larger studies with different ethnicities are required to validate our findings.
منابع مشابه
Lack of Association Between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...
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Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...
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عنوان ژورنال:
international journal of molecular and cellular medicineجلد ۴، شماره ۱، صفحات ۴۰-۴۵
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